Since vaccination has been at the top of our priority list for saving lives during this outbreak, could immunity in the nose help even more?
According to the researchers, a nasal spray vaccine against COVID-19 may be the most effective strategy to combat the novel coronavirus.
This is due to the fact that the virus normally enters the human body through the nasal route, and a spray would attack the invader there.
Currently, seven of the hundred COVID-19 vaccinations in clinical studies are nasal sprays.
China’s Xiamen University, the University of Hong Kong, and Beijing Wantai Biological Pharmacy are all well on their way to completing phase-2 studies.
The development of nasal spray vaccines, according to a March Scientific American article, can have an immediate effect on the virus in an infected person’s mucus. They cause the formation of an antibody called immunoglobulin A, which can prevent infection.
Thailand, on the other hand, plans to begin human trials of COVID-19 shots delivered by nasal spray.
“This overwhelming response, called sterilizing immunity, reduces the chance that people will pass on the virus,” said the article.
These shots provide excellent protection against severe COVID-19 strains. They are, however, less effective at preventing virus spread.
According to Mielcarek, directly stimulating immunity in the nose “lowers the danger of infecting other people.”
“From there, there is less virus infecting the lungs and thus fewer severe cases since the viral load is lower,” she noted.
In March, Gavi, the Vaccine Alliance, issued an article outlining the vaccine’s benefits. This includes the fact that these sprays will not need to be refrigerated and can be applied orally.
“Individuals would be able to self-administer them at home,” according to the article, and “they are likely to be more popular for the millions of people who don’t like needles.”
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